Английская Википедия:Cefradine
Шаблон:Short description Шаблон:Drugbox Cefradine (INN) or cephradine (BAN) is a first generation cephalosporin antibiotic.[1]
Indications
- Respiratory tract infections (such as tonsillitis, pharyngitis, and lobar pneumonia) caused by group A beta-hemolytic streptococci and S. pneumoniae (formerly D. pneumonia).[note 1]
- Otitis media caused by group A beta-hemolytic streptococci, S. pneumoniae, H. influenzae, and staphylococci.
- Skin and skin structure infections caused by staphylococci (penicillin-susceptible and penicillin-resistant) and beta-hemolytic streptococci.
- Urinary tract infections, including prostatitis, caused by E. coli, P. mirabilis and Klebsiella species.
Formulations
Cefradine is distributed in the form of capsules containing 250 mg or 500 mg, as a syrup containing 250 mg/5 ml, or in vials for injection containing 500 mg or 1 g.Шаблон:Cn
It is not approved by the FDA for use in the United States.Шаблон:Cn
Synthesis
Birch reduction of D-α-phenylglycine led to diene (2). This was N-protected using tert-butoxycarbonylazide and activated for amide formation via the mixed anhydride method using isobutylchloroformate to give 3. Mixed anhydride 3 reacted readily with 7-aminodesacetoxycephalosporanic acid to give, after deblocking, cephradine (5).
Production names
The antibiotic is produced under many brand names across the world.[5]
- Шаблон:Flagicon Bangladesh: Ancef, Ancef forte, Aphrin, Avlosef, Cefadin, Cephadin, Cephran, Cephran-DS, Cusef, Cusef DS, Dicef , Dicef forte, Dolocef, Efrad, Elocef, Extracef, Extracef-DS, Intracef, Kefdrin, Lebac, Lebac Forte, Medicef, Mega-Cef, Megacin, Polycef, Procef, Procef, Procef forte, Rocef, Rocef Forte DS, Sefin, Sefin DS, Sefnin, Sefrad, Sefrad DS, Sefril, Sefril-DS, Sefro, Sefro-HS, Sephar, Sephar-DS, Septa, Sinaceph, SK-Cef, Sk-Cef DS, Supracef and Supracef-F, Torped, Ultrasef, Vecef, Vecef-DS, Velogen, Sinaceph, Velox
- Шаблон:Flagicon China: Cefradine, Cephradine, Kebili, Saifuding, Shen You, Taididing, Velosef, Xianyi, and Xindadelei
- Шаблон:Flagicon Colombia: Cefagram, Cefrakov, Cefranil , Cefrex, and Kliacef
- Шаблон:Flagicon Egypt: Cefadrin, Cefadrine, Cephradine, Cephraforte, Farcosef, Fortecef, Mepadrin, Ultracef, and Velosef
- Шаблон:Flagicon France: Dexef
- Шаблон:Flagicon Hong Kong: Cefradine and ChinaQualisef-250
- Шаблон:Flagicon Indonesia: Dynacef, Velodine, and Velodrom
- Шаблон:Flagicon Lebanon: Eskacef, Julphacef, and Velosef
- Шаблон:Flagicon Lithuania: Tafril
- Шаблон:Flagicon Myanmar: Sinaceph
- Шаблон:Flagicon Oman: Ceframed, Eskasef, Omadine, and Velocef
- Шаблон:Flagicon Pakistan: Abidine, Ada-Cef, Ag-cef, Aksosef, Amspor, Anasef, Antimic, Atcosef, Bactocef, Biocef, Biodine, Velora, Velosef
- Шаблон:Flagicon Peru: Abiocef, Cefradinal, Cefradur, Cefrid, Terbodina II, Velocef, Velomicin
- Шаблон:Flagicon Philippines: Altozef, Racep, Senadex, Solphride, Yudinef, Zefadin, Zefradil, and Zolicef
- Шаблон:Flagicon Poland: Tafril
- Шаблон:Flagicon Portugal: Cefalmin, Cefradur
- Шаблон:Flagicon South Africa: Cefril A
- Шаблон:Flagicon South Korea: Cefradine and Tricef
- Шаблон:Flagicon Taiwan: Cefadin, Cefamid, Cefin, Cekodin, Cephradine, Ceponin, Lacef, Licef-A, Lisacef, Lofadine, Recef, S-60, Sefree, Sephros, Topcef, Tydine, Unifradine, and U-Save
- Шаблон:Flagicon UK: Cefradune (Kent)
- Шаблон:Flagicon Vietnam: Eurosefro and Incef
See also
- Cephapirin
- Cephacetrile
- Cefamandole
- Ampicillin (Has the same chemical formula)
Notes
References
Шаблон:CephalosporinAntiBiotics Шаблон:Xenobiotic-sensing receptor modulators
Ошибка цитирования Для существующих тегов <ref> группы «note» не найдено соответствующего тега <references group="note"/>
