Английская Википедия:Cephalon

Содержание

Текст

Текст

Текст

Текст

Текст

Текст

Текст

Текст

Текст

Шаблон:Short description Шаблон:For Шаблон:Multiple issues Шаблон:Use mdy dates Шаблон:Infobox company Cephalon, Inc. was an American biopharmaceutical company co-founded in 1987 by pharmacologist Frank Baldino, Jr., neuroscientist Michael Lewis, and organic chemist James C. Kauer—all three former scientists with the DuPont Company.Шаблон:Citation needed lead Baldino served as Cephalon's chairman and chief executive officer,Шаблон:Citation needed lead until his death in December 2010. The company's name comes from the adjective "cephalic" meaning "related to the head or brain", as it was established primarily to pursue treatments for neurodegenerative diseases.Шаблон:Citation needed lead

As noted by fundinguniverse.com, in its early years,

"Cephalon initially avoided involving itself in activities that would require maintaining a sales staff, managing clinical trials, and shepherding new drugs through the Food and Drug Administration (FDA) approval process. With no product to sell, Cephalon's only asset was its scientific expertise. That expertise proved sufficient to attract investors, and the company managed to fund its operations through research grants and contracts with larger pharmaceutical firms."

Cephalon was first included in the Fortune 1000 list of U.S. companies based upon annual revenues for 2006.Шаблон:Citation needed lead Sales revenues reached $2.8 billion in 2010,Шаблон:Citation needed lead ranking Cephalon among the leading biopharmaceutical companies in the world at that time.Шаблон:Citation needed lead

On May 2, 2011, Teva Pharmaceutical Industries announced it would acquire Cephalon.

Product development and acquisition history

Шаблон:Multiple issues The company's early research efforts were focused on the development of IGF-1, an insulin-like growth factor, in collaboration with Chiron Corporation, toward the development of a treatment for amyotrophic lateral sclerosis (Lou Gehrig's Disease), a candidate that was never approved.Шаблон:Cn

Thereafter, the company developed and commercialized products for the treatment of sleep disorders, pain, addiction and cancer,Шаблон:Cn establishing the "wake franchise"Шаблон:Cite quote on the basis of Provigil (modafinil) and later, Nuvigil, the R-enantiomer of modafinil.Шаблон:Cn In addition to conducting research on kinase inhibitors and other small molecules,Шаблон:Cn Cephalon licensed other compounds, purchased other products, and acquired entire companies, in the latter case, including CIMA Labs, Anesta, and Laboratoire Lafon.Шаблон:Cn It was from Lafon that Cephalon obtained the rights to modafinil, which it marketed under the trade name Provigil, for the treatment of excessive daytime sleepiness associated with narcolepsy, sleep apnea, and shift work sleep disorder.Шаблон:Cn Sales of Provigil reached nearly one billion dollars in 2008.Шаблон:Cn

In February 2009, Cephalon acquired the Australian biotechnology firm, Arana Therapeutics, which brought Cephalon its lead biologic candidate, ART621, a candidate for inflammatory diseases,Шаблон:Cn and biologics for the treatment of cancers.Шаблон:Verification neededШаблон:Cn Then, as infogrok.com noted in February 2010, "Cephalon... exercised its option to acquire Ception Therapeutics, following receipt of positive data from a clinical study in adults with eosinophilic asthma."Шаблон:Better source Commenting on this, Frank Baldino Jr., CEO of Cephalon, said, "The acquisition of Ception is consistent with our strategy to diversify into biologics and provides us with an important phase three asset for further development."Шаблон:Better source

At the time of Baldino's death in 2010, the company he had co-founded in 1987 was best known for the alertness drug Provigil, the painkiller Actiq, and the seizure disorder medication Gabitril. Шаблон:AnchorIn 2011, Cephalon agreed to acquire ChemGenex Pharmaceuticals, which would provided Cephalon with marketing rights to Omapro, a therapeutic agent for a drug-resistant leukemia, in the oncology therapeutic area.

Management and locations

Шаблон:Unreferenced section Longtime chief financial officer J. Kevin Buchi succeeded Baldino as CEO in 2011. Members of the board included:Шаблон:When venture capitalist William Egan, former COR Therapeutics CEO Vaughan Kailian, prominent healthcare economist Dr. Gail Wilensky, former SmithKline Beecham executive Dr. Martyn Greenacre, former Harvard physician and Glaxo USA head Dr. Charles Sanders and former Ambassador Kevin Moley.Шаблон:Cn

The company was headquartered west of Philadelphia, in Frazer, Pennsylvania, and had research operations in nearby West Chester and manufacturing and other operations in suburban Minneapolis, Minnesota and Salt Lake City, Utah.Шаблон:Cn European operations were based near Paris, France.Шаблон:Cn After the acquisition of Arana,Шаблон:When Research and Development operations continued in Sydney, Australia.Шаблон:Cn

Legal issues

In 1999 Cephalon settled a lawsuit for $17 million in which it had faced claims that Baldino and other company executives had overstated the potential for a drug aimed at treating amyotrophic lateral sclerosis (Lou Gehrig's disease). In addition, the Federal Trade Commission filed suit against Cephalon,Шаблон:When stating that it had made "illegal deals with generic drug companies to delay generic competition to Provigil", an accusation that Cephalon has reportedly disputed.Шаблон:Update after In September 2008, Cephalon paid $425 million to the federal government to settle four whistleblower lawsuits and a criminal charge alleging Cephalon had marketed Actiq, Gabitril and Provigil for “off-label” (unapproved) uses.Шаблон:Better source

Products

Шаблон:Unreferenced section Select products that Cephalon manufactured and marketed included:Шаблон:WhenШаблон:Cn Шаблон:Div col

• Actiq (fentanyl citrate)
• Amrix (cyclobenzaprine)
• Fentora (fentanyl)
• Gabitril (tiagabine)
• Nuvigil (armodafinil)
• Provigil (modafinil)
• Treanda (bendamustine HCl)
• Trisenox (arsenic trioxide)

External links

• Шаблон:Official website (Teva Pharmaceutical)