Английская Википедия:Chaetochromin

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Chaetochromin, also known as 4548-G05, is an orally active, small-molecule, selective agonist of the insulin receptor.[1] It has potent and long-lasting antidiabetic activity in vivo in mice.[1] The drug may represent a novel potential therapeutic agent for the treatment of diabetes which is more convenient and tolerable to administer than injected insulin.[1] It was discovered in 1981 in Chaetomium gracile fungi,[2] and its interaction with the insulin receptor was identified in 2014.[1]

Stereochemistry

Chaetochromin A and B are stereoisomers of this structure, while chaetochromin C and D are related but different compounds.[3] It is not known whether the insulin mimetic effect was found in chaetochromin A or B, or in a mixture.[1]

See also

References

Шаблон:Reflist