Английская Википедия:Chaetoglobosin A

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Шаблон:Chembox

Файл:Chaetoglobosin A NRPS-PKS.tif
Proposed PKS-NRPS organization responsible for production of (1) in the biosynthesis of chaetoglobosin A.

Chaetoglobosin A is a fungal isolate with anticancer activity in vitro.[1] Derivatives of the compound include MBJ-0038, MBJ-0039, and MBJ-0040.[2]

Biosynthesis

Chaetoglobosin A biosynthesis begins with a product from hybrid PKS-NRPS encoded by the gene CHGG_01239, followed by multiple oxidations which form different intermediates depending on the order of functional groups oxidized. The PKS-NRPS product undergoes a diels alder, to form Шаблон:Chem name I (2) and is subsequently oxidized in different paths as shown in the scheme. Either the epoxide is created first to form Шаблон:Chem name IV (5), followed by di-hydroxylation to form 20-dihydrochaetoglobosin A (6), and a final oxidation of one hydroxyl to ketone to form chaetoglobosin A, or di-hydroxylation of (2) occurs first, forming cytoglobosin D (3), followed by one hydroxyl oxidation to form chaetoglobosin J (4), and lastly epoxidation to form chaetoglobosin A. Epoxidation of (3) can also occur prior to hydroxyl oxidation to form (6). [3]

Файл:Chaetoglobosin A bisynthetic scheme.svg
Proposed biosynthesis of chaetoglobosin A from (1) as described in "Biosynthesis"

References

Шаблон:Reflist