Английская Википедия:Cimemoxin

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Шаблон:Short description Шаблон:Drugbox Cimemoxin (INN), or cyclohexylmethylhydrazine, is a hydrazine monoamine oxidase inhibitor (MAOI) antidepressant which was never marketed.[1]

Synthesis

It possesses 50 times the relative activity of iproniazid and 25x nialamide (see patent).

Файл:Cimemoxin synthesis.svg
Synthesis:[2][3][4]

3-Cyclohexene-1-carbaldehyde [100-50-5] (aka 1,2,3,6-Tetrahydrobenzaldehyde) is reacted with N-acetylhydrazine to give the hydrazone, which is reduced by catalytic hydrogenation. The acetyl group is removed by acid hydrolysis.

See also

References

Шаблон:Reflist

Шаблон:Antidepressants Шаблон:Navboxes


Шаблон:Nervous-system-drug-stub