Английская Википедия:Class C GPCR

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Шаблон:Short description Шаблон:Pfam box

The class C G-protein-coupled receptors (Шаблон:InterPro) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (Шаблон:InterPro) and several additional receptors.[1]

Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length.[1] This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.

Subfamilies

Calcium-sensing receptor-related

GABAB receptors

Metabotropic glutamate receptors

RAIG

Taste receptors

Orphan

Other

References

Шаблон:Reflist

Шаблон:G protein-coupled receptors Шаблон:Transmembranereceptor-stub