Английская Википедия:Class I PI 3-kinases

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Class I PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase that possess a common protein domain structure, substrate specificity, and method of activation. Class I PI 3-kinases are further divided into two subclasses, class IA PI 3-kinases and class IB PI 3-kinases.

Class IA PI 3-kinases

Class IA PI 3-kinases are activated by receptor tyrosine kinases (RTKs).

There are three catalytic subunits that are classified as class IA PI 3-kinases:Шаблон:Citation needed

There are currently five regulatory subunits that are known to associate with class IA PI 3-kinases catalytic subunits:Шаблон:Citation needed

Class IB PI 3-kinases

Class IB PI 3-kinases are activated by G-protein-coupled receptors (GPCRs).

The only known class IB PI 3-kinase catalytic subunit is p110γ.

There are two known regulatory subunits for p110γ:

See also

References

Шаблон:Kinases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:2.7-enzyme-stub Шаблон:Cell-biology-stub