Английская Википедия:Clonixin

Материал из Онлайн справочника
Перейти к навигацииПерейти к поиску

Шаблон:Short description Шаблон:Chembox

Clonixin is a nonsteroidal anti-inflammatory drug (NSAID). It also has analgesic, antipyretic, and platelet-inhibitory actions. It is used primarily in the treatment of chronic arthritic conditions and certain soft tissue disorders associated with pain and inflammation.

Synthesis

Файл:Clonixin synthesis.svg
Clonixin synthesis: M. H. Sherlock, N. Sperber, Шаблон:Cite patent; eidem, Шаблон:US patent (1966, 1967 both to Schering).

Clonixeril

The glyceryl ester of clonixin, clonixeril, is also an NSAID. It was prepared by a somewhat roundabout method.

Файл:Clonixeril synthesis.svg
Clonixeril synthesis:[1][2]

Clonixin was reacted with chloroacetonitrile and triethylamine to give 2. Heating with potassium carbonate and glycerol acetonide displaced the activating group to produce ester 3, which was deblocked in acetic acid to produce clonixeril (4).

See also

References

Шаблон:Reflist

Шаблон:Prostanoidergics


Шаблон:Musculoskeletal-drug-stub

  1. M. H. Sherlock, Шаблон:Cite patent (1968); Chem. Abstr., 70: 96640c (1969).
  2. Шаблон:Cite patent (1973); Chem. Abstr., 79: 18582g (1973).