Английская Википедия:Cyclotriol

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Cyclotriol (developmental code name ZK-136295; also known as 14α,17α-ethanoestriol) is a synthetic estrogen which was studied in the 1990s and was never marketed.[1][2][3][4] It is a derivative of estriol with a bridge between the C14α and C17α positions.[1][2][3][5] The drug has 40% of the relative binding affinity of estradiol for the human ERα.[1] It showed an absolute bioavailability of 40% with high interindividual variability and an elimination half-life of 12.3 hours in pharmacokinetic studies in women.[2]

See also

References

Шаблон:Reflist

Шаблон:Estrogen receptor modulators

Шаблон:Steroid-stub Шаблон:Genito-urinary-drug-stub