Английская Википедия:Cytochrome b5 reductase

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Шаблон:Short description Шаблон:Infobox enzyme Шаблон:Pfam box Cytochrome-b5 reductase is a NADH-dependent enzyme that converts ferricytochrome from a Fe3+ form to a Fe2+ form.[1] It contains FAD and catalyzes the reaction: Шаблон:Center In its b5-reducing capacity, this enzyme is involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, and drug metabolism.

This enzyme can also reduce methemoglobin to normal hemoglobin, gaining it the inaccurate synonym methemoglobin reductase. Isoforms expressed in erythrocytes (CYB5R1, CYB5R3) perform this function in vivo. Ferricyanide is another substrate in vitro.Шаблон:Citation needed

The following four human genes encode cytochrome-b5 reductases:Шаблон:Citation needed

See also

References

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External links

Шаблон:Flavoproteins Шаблон:NADH or NADPH oxidoreductases Шаблон:Enzymes Шаблон:Portal bar