Английская Википедия:DNAJB6

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Шаблон:Short description Шаблон:Cs1 config Шаблон:Infobox gene DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.[1][2][3]

Function

This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.[3]

Interactions

DNAJB6 has been shown to interact with keratin 18.[4] It has been also shown that the aggregation of Aβ42 (a process involved in e.g. Alzheimer's disease) is retarded by DNAJB6 in a concentration-dependent manner, extending to very low sub-stoichiometric molar ratios of chaperone to peptide.[5] Dominant mutations in DNAJB6 have also been found to cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology.[6]

References

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Further reading

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External links

Шаблон:Chaperones