Английская Википедия:Daniela Rhodes

Материал из Онлайн справочника
Перейти к навигацииПерейти к поиску

Шаблон:Short description Шаблон:EngvarB Шаблон:Use dmy dates Шаблон:Infobox scientist

Daniela Bargellini Rhodes FRS[1] (born 1946) is an Italian structural and molecular biologist. She was a senior scientist at the Laboratory of Molecular Biology in Cambridge, England,[2] where she worked, and later studied for her PhD[3] under the supervision of Nobel laureate Aaron Klug. Continuing her work under the tutelage of Aaron Klug at Cambridge, she was appointed group leader in 1983, obtained tenure in 1987 and was promoted to senior scientist in 1994 (equivalent to full professor). Subsequently, she served as director of studies between 2003 and 2006. She has also been visiting professor at both "La Sapienza" in Rome, Italy and the Rockefeller University in NY, USA.[4][5][6][7][8]

Career and research

Daniela Rhodes has made many fundamental contributions to understanding the structure and function of nucleic acids and their biologically important interactions with many different proteins. Her work combines biochemical analyses with direct structural determination. She determined the structures of a number of important protein-DNA complexes involved in transcription, such as zinc-fingers and nuclear hormone receptors. She has provided some of the first structural information on telomeric proteins, such as yeast Rap1p and human TRF1 and TRF2 and their complexes with DNA. Throughout her career she has made many contributions to the understanding of chromatin structure and function. She was involved in determining the structure of the nucleosome core particle, has worked on transcriptionally active chromatin and more recently on the higher order 30nm structure of chromatin.[2] Her research continues to focus on understanding how the structure of chromatin is involved in transcriptional regulation and how telomeres are involved in preserving chromosome integrity.[9]

She joined the School of Biological Sciences at Nanyang Technological University (NTU), in Singapore, as professor in September 2011[10] and was additionally appointed professor at the Lee Kong Chian School of Medicine in September 2012.[11] In April 2014 she was appointed Director of the newly formed Nanyang Institute of Structural Biology.

Daniela left NTU in 2020 and is an Emeritus Scientist at the Laboratory of Molecular Biology.

Awards and honours

References

Шаблон:Reflist

Шаблон:FRS 2007 Шаблон:Authority control

  1. 1,0 1,1 Ошибка цитирования Неверный тег <ref>; для сносок frs не указан текст
  2. 2,0 2,1 Шаблон:Cite web
  3. Шаблон:Cite thesis
  4. "Analysis of sequence-specific DNA-binging proteins", Protein function: a practical approach, Editor Thomas E. Creighton, Oxford University Press, 1997, Шаблон:ISBN
  5. "The Role of Histone H1 in Chromatin Condensation and Transcriptional Repression", Structural biology and functional genomics, Editors E. Morton Bradbury, Sándor Pongor, Springer, 1999, Шаблон:ISBN
  6. "Telomeric DNA Recoginition", RNA biochemistry and biotechnology, Volume 1998, Editors Jan Barciszewski, Brian Frederic Carl Clark, Springer, 1999, Шаблон:ISBN
  7. "Structure of the 30nm Chromatin Fibre and the Regulation of Its Compaction" Шаблон:Cite web
  8. Daniela Rhodes's profile at Scientific Commons
  9. LMB Web-page Шаблон:Webarchive
  10. Шаблон:Cite web
  11. Шаблон:Cite web
  12. Шаблон:Cite web
  13. Ошибка цитирования Неверный тег <ref>; для сносок MPC-object не указан текст
  14. Ошибка цитирования Неверный тег <ref>; для сносок MPC-Circulars-Archive не указан текст