Английская Википедия:Defactinib

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Шаблон:Short description Шаблон:Infobox drug Defactinib (INN, codenamed VS-6063) is an inhibitor of PTK2, also known as focal adhesion kinase (FAK), Pyk2, and MELK which was developed by Pfizer and licensed to Verastem Oncology as a potential treatment for solid tumors.

Development for mesothelioma was discontinued in 2015 due to lack of efficacy in a placebo-controlled phase II trial.[1][2] Subsequent research in patients with specific NF2 mutations also found limited activity.[3]

As of 2022, it remains in trials in combination with other medications for other types of cancer.

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