Английская Википедия:Diaminopyrimidine

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Шаблон:Short description Diaminopyrimidines (DAP) are a class of organic chemical compounds that include two amine groups on a pyrimidine ring.

Файл:Iclaprim.svg
Iclaprim
Файл:Trimethoprim.svg
Trimethoprim

They include many dihydrofolate reductase inhibitor drugs (such as pyrimethamine, trimetrexate, and piritrexim[1] and the antibiotics Iclaprim and trimethoprim).

Some have been patented as anti-cancer drugs.[2]

See also

References

Шаблон:Reflist


Шаблон:Organic-compound-stub

  1. http://aac.asm.org/cgi/content/full/45/12/3293 Шаблон:Webarchive "Dicyclic and Tricyclic Diaminopyrimidine Derivatives as Potent Inhibitors of Cryptosporidium parvum Dihydrofolate Reductase: Structure-Activity and Structure-Selectivity Correlations" Nelson et al. 2001
  2. Шаблон:Cite web