Английская Википедия:Diclofensine
Шаблон:Short description Шаблон:Cs1 config Шаблон:Drugbox
Diclofensine (Ro 8-4650) was developed by Hoffmann-La Roche in the 1970s[1] in the search for a new antidepressant. It was found that the (S)-isomer was responsible for activity.[2] Diclofensine is a stimulant drug which acts as a triple monoamine reuptake inhibitor,[3][4] primarily inhibiting the reuptake of dopamine[5] and norepinephrine,[6] with affinities (Ki) of 16.8 nM, 15.7 nM, and 51 nM for DAT, NET, and SERT (dopamine, norepinephrine and serotonin transporters), respectively.[7] It was found to be an effective antidepressant in human trials,[8][9][10] with relatively few side effects,[11] but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential.[12][13]
Diclofensine is chemically a tetrahydroisoquinoline (THIQ) derivative, as is nomifensine.
Synthesis
The condensation of m-anisaldehyde [591-31-1] (1) with methylamine gives N-methyl-3-methoxybenzenemethanimine [16928-30-6]. Reduction of this Schiff-base intermediate with sodium borohydride gives (3-methoxybenzyl)methylamine [41789-95-1] (2). Alkylation of this with 3,4-dichlorophenacylbromide [2632-10-2] (3) would give CID:59580342 (4). Reduction of the benzoyl ketone with sodium borohydride gives the alcohol [802051-24-7] (5). Acid catalyzed intramolecular cyclization then completes the synthesis of the 4-aryl-THIQ derivative, diclofensine (6).
See also
References
Шаблон:Antidepressants Шаблон:Stimulants Шаблон:Monoamine reuptake inhibitors
- ↑ Шаблон:Cite patent
- ↑ Шаблон:Cite book
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Rheiner Alfred Jr Dr, Шаблон:Cite patent (1973 to Hoffmann La Roche).
- ↑ Alfred Rheiner, Шаблон:US patent (1976 to Hoffman-La Roche Inc.).
- ↑ Shuang Liu, Bruce F. Molino, Kassoum Nacro, Шаблон:Cite patent (2010 to Albany Molecular Reserch, Inc.). Page column 32.
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