Английская Википедия:Dihydrofolic acid

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Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a folic acid (vitamin B9) derivative which is converted to tetrahydrofolic acid by dihydrofolate reductase.[1] Since tetrahydrofolate is needed to make both purines and pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid synthesis.

Файл:Pathway of tetrahydrofolate and antimetabolites.pdf
Pathway of tetrahydrofolate and antimetabolites

Interactive pathway map

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Further reading

References

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