Английская Википедия:Distamycin

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Distamycin is a polyamide-antibiotic, which acts as a minor groove binder, binding to the small furrow of the double helix.[1]

Properties

Distamycin is a pyrrole-amidine antibiotic and analogous to netropsin and the class of lexitropsins. As opposed to netropsin, distamycin contains three N-methyl-pyrrole units. It is harvested from Streptomyces netropsis that also produces netropsin. Distamycin prefers AT-rich DNA-sequences and tetrades of [TGGGGT]4.[2][3] Distamycin inhibits the transcription and increases the activity of the topoisomerase II.[4][5] Derivates from distamycin are used as alkylating antineoplastic agents to combat tumours.[1][6] Derivates with fluorophores are used as fluorescent tags for double-stranded DNA.[7]

The compound is hygroscopic, and sensible to light, freeze and hydrolysis. Its molar attenuation coefficient is 37,000 M−1 cm−1 at a wavelength of 303 nm.

See also

References

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