Английская Википедия:Dornase alfa

Материал из Онлайн справочника
Перейти к навигацииПерейти к поиску

Шаблон:Short description Шаблон:Medref Шаблон:Drugbox

Dornase alfa, sold under the brand name Pulmozyme, is used for the treatment of cystic fibrosis.[1] It is a recombinant human deoxyribonuclease I (rhDNase), an enzyme which selectively cleaves DNA.[1] Dornase alfa hydrolyzes the DNA present in sputum/mucus and reduces viscosity in the lungs, promoting improved clearance of secretions.[1] It is produced in Chinese hamster ovary cells.[1]

Medical uses

Dornase alfa is indicated for the management of people with cystic fibrosis to improve pulmonary function.[1]

Society and culture

Legal status

Dornase alfa is an orphan drug.[2]

Research

Dornase alfa has been shown to improve lung function in non-cystic fibrosis pre-term infants atelectasis.[3][4]

References

Шаблон:Reflist

Шаблон:Cough and cold preparations Шаблон:Portal bar

de:Desoxyribonuklease#Verwendung als Arzneistoff

  1. 1,0 1,1 1,2 1,3 1,4 Ошибка цитирования Неверный тег <ref>; для сносок Pulmozyme FDA label не указан текст
  2. Шаблон:Cite journal
  3. Шаблон:Cite journal
  4. Шаблон:Cite journal