Английская Википедия:E. coli nitroreductase

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Шаблон:Short description Шаблон:One source E. coli nitroreductase is a flavoprotein found in the bacteria Escherichia coli. It catalyses the reduction of nitro groups in a wide range of substrates to produce the corresponding hydroxylamine. Although its role in vivo is unclear, it has been identified as useful in the metabolism of a number of prodrugs in anti-cancer gene therapy.[1]

There are at least two oxygen-insensitive nitroreductases in E. coli. The major one is NfsA (Шаблон:UniProt, EC 1.7.1.B3).[2] The other is NfsB (Шаблон:UniProt, EC 1.5.1.34).[3]

See also

References

  1. Denny, W.A. "Nitroreductase-based GDEPT" Current Pharmaceutical Design, 2002, 8(15), 1349–1361.
  2. Шаблон:Cite journal
  3. Шаблон:Cite journal


Шаблон:Protein-stub