Английская Википедия:ERB-79

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ERB-79 is a synthetic estrogen and a selective agonist of the ERβ.[1][2][3] It is a racemic mixture, with the active enantiomer being ERB-26.[2] ERB-79 shows more than 484-fold selectivity for transactivation of the ERβ over the ERα.[1] Its EC50 value for the ERβ is 0.448 nM (14.52% of the potency of estradiol) and for the ERα is 79 nM (0.03% of the potency of estradiol).[1] It has no antagonistic activity at either receptor.[1] ERB-79 is active in preclinical models of arthritis.[1] The chemical structure of ERB-79 does not appear to have been disclosed.

See also

References

Шаблон:Reflist


Шаблон:Estrogen receptor modulators


Шаблон:Genito-urinary-drug-stub