She received her education Tbilisi N. Skliphosofsky Art Studio. She traveled to Moscow and got impressed by Vrubel’s paintings. In 1919 she participated in Georgian artists exhibition. In 1921 continues studies at Tbilisi Art Academy in G. Gabashvili class. In 1922 she left for Italy for further studies and traveled to Rome, Milan, Florence and Venice for 6 months. In 1924, Akhvlediani began studying at Académie Colarossi in Paris, where her main field of work – urban landscapes – elaborated. By this time she made the whole series of Parisian views. It is also in Paris that a big graphic series of her up till now less known Nude is created. Obviously, she never returned to it back in Soviet Georgia [1].
Like her avant-garde colleague Lado Gudiashvili, Akhvlediani faced persecution under Stalin but was widely celebrated by the 1970s. Her landscapes of Old Tbilisi, in particular, were embraced during the late Soviet period's revival of interest in urban folk culture. Akhvlediani appears as herself (alongside Lado Gudiashvili) in Temur Palavandishvili's 1973 film Mze Shemodgomisa (Autumn Sun), in which a stifled artist moves to Ortachala from his sterile postwar flat and finds inspiration in the city's historic architecture. To this day, many painters of Old Tbilisi buildings wittingly or unwittingly emulate Akhvlediani's style.[3]