Английская Википедия:Enolase 2

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Шаблон:Short description Шаблон:Cs1 config Шаблон:Infobox gene Gamma-enolase, also known as enolase 2 (ENO2) or neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene.[1][2] Gamma-enolase is a phosphopyruvate hydratase.

Gamma-enolase is one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates.[1]

Interactive pathway map

Шаблон:GlycolysisGluconeogenesis WP534

Utility

Файл:Hemangioblastoma - nse - high mag.jpg
Neuron-specific enolase (NSE) immunostaining of a cerebellar hemangioblastoma.

Detection of NSE with antibodies can be used to identify neuronal cells and cells with neuroendocrine differentiation. NSE is produced by small-cell carcinomas, which are neuroendocrine in origin. NSE is therefore a useful tumor marker for distinguishing small-cell carcinomas from other tumors.[3]

References

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Further reading

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External links

Шаблон:PDB Gallery Шаблон:Carbon-oxygen lyases Шаблон:Enzymes Шаблон:Portal bar Шаблон:Tumor markers