Английская Википедия:Enoyl-acyl carrier protein reductase

Материал из Онлайн справочника
Перейти к навигацииПерейти к поиску

Шаблон:Short description Шаблон:Infobox enzyme Enoyl-acyl carrier protein reductase (or ENR) (Шаблон:EC number), is a key enzyme of the type II fatty acid synthesis (FAS) system.[1] ENR is an attractive target for narrow-spectrum antibacterial drug discovery because of its essential role in metabolism and its sequence conservation across many bacterial species. In addition, the bacterial ENR sequence and structural organization are distinctly different from those of mammalian fatty acid biosynthesis enzymes.[2]

Файл:FattyAcid-MB-Reduction2.svg

At lower concentrations, Triclosan and Triclocarban provide a bacteriostatic effect by binding to ENR. Atromentin and leucomelone possess antibacterial activity, inhibiting the enzyme in the bacteria Streptococcus pneumoniae.[3]

See also

References

Шаблон:Reflist

External links

Шаблон:Lipid metabolism enzymes Шаблон:CH-CH oxidoreductases Шаблон:Enzymes Шаблон:Portal bar