Английская Википедия:Estrogen conjugate

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Шаблон:Short description Шаблон:Distinguish

Файл:Estrone sulfate.svg
Estrone sulfate, the 3-sulfate conjugate of estrone.
Файл:Estriol glucuronide.svg
Estriol glucuronide, the 16α-glucuronide conjugate of estriol.

An estrogen conjugate is a conjugate of an endogenous estrogen. They occur naturally in the body as metabolites of estrogens and can be reconverted back into estrogens. They serve as a circulating reservoir for estrogen, particularly in the case of orally administered pharmaceutical estradiol. Estrogen conjugates include sulfate and/or glucuronide conjugates of estradiol, estrone, and estriol:

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Estrogen conjugates are conjugated at the C3, C16α, and/or C17β positions, where hydroxyl groups are available.[1]

Estrogen conjugates have been used as pharmaceutical estrogens, as in estrone sulfate as estropipate (piperazine estrone sulfate) and in conjugated estrogens (Premarin) and conjugated estriol (Progynon, Emmenin).

Шаблон:Affinities and estrogenic potencies of estrogen esters and ethers at the estrogen receptors

Шаблон:Affinities of estrogen receptor ligands for the ERα and ERβ

See also

References

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Шаблон:Steroid hormones Шаблон:Estrogen receptor modulators