Английская Википедия:Etidocaine

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Шаблон:Short description Шаблон:Drugbox Etidocaine, marketed under the trade name Duranest, is an amide-type local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.[1]

Synthesis

Файл:Etidocaine synthesis.svg
Patent:[2] 2-bromobutyryl chloride synthesis:[3]

The amide reaction between 2,6-xylidine (1) and 2-bromobutyryl chloride [22118-12-3] (2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide [53984-81-9] (3). Alkylation with N-Ethylpropylamine [20193-20-8] (4) gives Etidocaine (5).

References

Шаблон:Reflist

External links

Шаблон:Local anesthetics

Шаблон:Nervous-system-drug-stub

  1. Шаблон:Cite journal
  2. DE2162744 idem H Adams, G Kronberg, B Takman, Шаблон:US patent (1974 to Astra Pharma Prod).
  3. Org. Synth. 1950, 30, 62. DOI: 10.15227/orgsyn.030.0062