Английская Википедия:Etifelmine

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Шаблон:Short description Шаблон:Drugbox

Etifelmine (INN; also known as gilutensin) is a stimulant drug. It was used for the treatment of hypotension (low blood pressure).[1]

Synthesis

Файл:Etifelmine synthesis.svg
Thieme Patent:[2]

The base catalyzed reaction between benzophenone [119-61-9] (1) and butyronitrile [109-74-0] (2) gives 2-[hydroxy(diphenyl)methyl]butanenitrile [22101-20-8] (3). Catalytic hydrogenation reduces the nitrile group to a primary amine giving 1,1-diphenyl-2-ethyl-3-aminopropanol [22101-87-7] (4). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of Etifelmine (5).

See also

References

  1. Шаблон:Cite journal
  2. Dr Werner Heinrich & Dr Walter Heigel, Шаблон:Cite patent (1962 to Giulini Gmbh Geb).

Шаблон:Stimulants Шаблон:Monoamine releasing agents

Шаблон:Nervous-system-drug-stub