Английская Википедия:Etrasimod
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Etrasimod, sold under the brand name Velsipity, is a medication that is used for the treatment of ulcerative colitis.[1] It is a selective sphingosine-1-phosphate (S1P) receptor modulator that modifies the activity of the immune system.[1] It is taken by mouth.[1]
The most common side effects include lymphopenia (low levels of lymphocytes) and headache.[2]
Etrasimod was discovered by Arena Pharmaceuticals, with subsequent development by Pfizer.[3] Etrasimod was approved for medical use in the United States in October 2023,[1] and in the European Union in February 2024.[2]
Medical uses
Etrasimod is used for the treatment of moderate to severe ulcerative colitis.[1][2]
Mechanism of action
It works by causing T cells to become trapped in the lymph nodes, preventing them from entering the bloodstream, from where they would travel to other tissues in the body and mediate inflammation.[4][5][6][7][8][9]
Society and culture
Legal status
Velsipity was approved by the US Food and Drug Administration (FDA) in October 2023.[1][10][11]
In December 2023, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Velsipity, intended for the treatment of ulcerative colitis.[2] The applicant for this medicinal product is Pfizer Europe MA EEIG.[2] Etrasimod was approved for medical use in the European Union in February 2024.[2]
Names
Etrasimod is the international nonproprietary name.[12]
References
Шаблон:Immunosuppressants Шаблон:Lysophospholipid signaling modulators Шаблон:Portal bar Шаблон:Authority control
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<ref>; для сносокVelsipity FDA labelне указан текст - ↑ 2,0 2,1 2,2 2,3 2,4 2,5 Шаблон:Cite web Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
- ↑ Шаблон:Cite web
- ↑ Шаблон:Cite journal
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- ↑ Шаблон:Cite web
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- Английская Википедия
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