Английская Википедия:Examples of in vivo transdifferentiation by lineage-instructive approach

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Шаблон:Short description A list of examples of in vivo transdifferentiation through transfection:[1]

  • mouse hepatocytes → B cells (Pdx1)[2]
  • exocrine cells → B cells (Pdx1, Ngn3, and v-maf musculoaponeurotic fibrosarcoma oncogene family protein A)[3]
  • nonsensory cells → inner hair cells (Atoh1 and MathI)[4]
  • non cardiogenic mesoderm → cardiomyocytes (Gata4, Tbx5 and Smarcd3 or Baf60c)[5]

Through excision:

  • B-cell precursors → hematopoietic progenitors(-Pax5)[6]
  • In adult ovarian follicles, granulosa and thecal cells → functional Sertoli-like and Leydig-like cells (-Foxl1)[7]

See also

References