Английская Википедия:Filaminast

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Filaminast (code name WAY-PDA 641)[1] was a drug candidate developed by Wyeth-Ayerst.[2]Шаблон:Rp It is a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and an analog of rolipram, which served as a prototype molecule for several development efforts.[3][4]Шаблон:Rp It was discontinued after a Phase II trial showed that its therapeutic window was too narrow; it could not be dosed high enough without causing significant side effects (nausea and vomiting), which was a problem with the rolipram class of molecules.[4]Шаблон:Rp

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References

Шаблон:Reflist

Шаблон:Phosphodiesterase inhibitors Шаблон:Drugs for obstructive airway diseases