Английская Википедия:Frizzled-8

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Шаблон:Short description Шаблон:Infobox gene Frizzled-8 (Fz-8) is a protein that in humans is encoded by the FZD8 gene.[1][2]

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.[2]

References

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Further reading

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External links


Шаблон:PDB Gallery Шаблон:G protein-coupled receptors

Шаблон:NLM content Шаблон:Transmembranereceptor-stub