Английская Википедия:Furonazide

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Шаблон:Chembox

Furonazide is a crystalline tuberculostatic drug substance with a reported melting point of 199-201.5 °C.[1]

Synthesis

Furonazide was first prepared in 1955 by Miyatake from isoniazid and 2-Acetylfuran by refluxing in ethanol, followed by filtration of the crystalline product.[1][2]

Applications

Furonazide has shown bacteriostatic action and is tuberculostatic at levels of 10−8 molar.[1] The in vitro antibacterial activity of furonazide against Bacillus Calmette-Guerin was found to be essentially equal to that of isoniazid on an equimolar basis.[3] In vivo studies in the guinea pig showed furonazide slightly more active than isoniazid as a tuberculostatic agent.[4] The drug has relatively low toxicity. The median lethal dose (LD50, rat oral) was reported as 2,600 mg/kg.[5]

References

Шаблон:Reflist

  1. 1,0 1,1 1,2 Kazuo Miyatake, “Derivatives of isonicotinic acid hydrazide”, Japanese Patent 32,002,484 B4 (1957)
  2. Шаблон:Cite journal
  3. Шаблон:Cite journal
  4. Шаблон:Cite journal
  5. "Drugs - Synonyms and Properties" data were obtained from Ashgate Publishing Co. (US)