Английская Википедия:GRN-529

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Шаблон:Short description Шаблон:Drugbox

GRN-529 is a drug that was developed by Wyeth as a negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5).[1]

A study conducted by Pfizer found that GRN-529 reduced repetitive behaviors without sedation and partially increased sociability in mouse models of autism. [2]

Another study conducted by Pfizer found a therapeutically relevant effect in animal models of depression. It is theorized to work by reducing glutamate receptor hyperactivity.[3]

See also

References

Шаблон:Reflist

External links

Шаблон:Metabotropic glutamate receptor modulators

Шаблон:Nervous-system-drug-stub