Английская Википедия:Gastric chief cell

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Шаблон:Short description Шаблон:Infobox anatomy A gastric chief cell, peptic cell, or gastric zymogenic cell is a type of gastric gland cell that releases pepsinogen and gastric lipase. It is the cell responsible for secretion of chymosin in ruminant animals and humans.[1] The cell stains basophilic upon H&E staining due to the large proportion of rough endoplasmic reticulum in its cytoplasm. Gastric chief cells are generally located deep in the mucosal layer of the stomach lining, in the fundus and body of the stomach.[2][3]

Chief cells release the zymogen (enzyme precursor) pepsinogen when stimulated by a variety of factors including cholinergic activity from the vagus nerve and acidic condition in the stomach. Gastrin and secretin may also act as secretagogues.[4]

It works in conjunction with the parietal cell, which releases gastric acid, converting the pepsinogen into pepsin.

Nomenclature

The terms chief cell and zymogenic cell are often used without the word "gastric" to name this type of cell. However, those terms can also be used to describe other cell types (for example, parathyroid chief cells). Chief cells are also known as peptic cells.

See also

References

Шаблон:Reflist

External links

Шаблон:Gastrointestinal physiology Шаблон:Authority control

  1. Шаблон:Cite journal
  2. Шаблон:Cite web Topic Completed: 28 May 2020. Minor changes: 28 December 2020
  3. pathologyoutlines.com/topic/stomachnormalhistology.html
  4. Шаблон:Cite book