Английская Википедия:Glucocerebroside

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Шаблон:Short description Glucocerebroside (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose.

Файл:グルコシルセラミド.jpg
A glucocerebroside
Файл:Beta-D-Glucose.svg
glucose
Файл:Sphingolipid.png
sphingolipid

Clinical significance

In Gaucher's disease, the enzyme glucocerebrosidase is nonfunctional and cannot break down glucocerebroside into glucose and ceramide in the lysosome.[1] Affected macrophages, called Gaucher cells, have a distinct appearance similar to "wrinkled tissue paper" under light microscopy, because the substrates build-up within the lysosome. [2]

See also

References

Шаблон:Reflist

External links

Шаблон:Sphingolipids


Шаблон:Biochem-stub