Английская Википедия:Glycerate kinase

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In enzymology, a glycerate kinase (Шаблон:EC number) is an enzyme that catalyzes the chemical reaction

ATP + (R)-glycerate <math>\rightleftharpoons</math> ADP + 3-phospho-(R)-glycerate

or

ATP + (R)-glycerate <math>\rightleftharpoons</math> ADP + 2-phospho-(R)-glycerate

Thus, the two substrates of this enzyme are ATP and (R)-glycerate, whereas its two products are ADP and either 3-phospho-(R)-glycerate or 2-phospho-(R)-glycerate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:(R)-glycerate 3-phosphotransferase. Other names in common use include glycerate kinase (phosphorylating), D-glycerate 3-kinase, D-glycerate kinase, glycerate-3-kinase, GK, D-glyceric acid kinase, and ATP:D-glycerate 2-phosphotransferase. This enzyme participates in 3 metabolic pathways: serine/glycine/threonine metabolism, glycerolipid metabolism, and glyoxylate-dicarboxylate metabolism.

This enzyme had been thought to produce 3-phosphoglycerate, but some glycerate kinases produce 2-phosphoglycerate instead.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.

References

• Шаблон:Cite journal
• Шаблон:Cite journal

Шаблон:2.7-enzyme-stub