Английская Википедия:Glycerol kinase

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Шаблон:Short description Шаблон:Enzyme

Шаблон:Infobox protein Glycerol kinase, encoded by the gene GK, is a phosphotransferase enzyme involved in triglycerides and glycerophospholipids synthesis.

Glycerol kinase catalyzes the transfer of a phosphate from ATP to glycerol thus forming glycerol 3-phosphate:

ATP + glycerol <=> ADP + sn-glycerol 3-phosphate

Adipocytes lack glycerol kinase so they cannot metabolize the glycerol produced during triacyl glycerol degradation. This glycerol is instead shuttled to the liver via the blood where it is:

Enzyme regulation

This protein may use the morpheein model of allosteric regulation.[1]

Structure

Glycerol Kinase (alternative name, ATP:glycerol 3-phosphotransferase or Glycerokinase) adopts a ribonuclease H-like fold consisting of an alpha-beta 2-layer sandwich of CATH family 3.30.420.40. Шаблон:As of, there were 20 structures of this protein in the PDB, most of which are homodimeric.

See also

External links

References

Шаблон:Reflist

Шаблон:Kinases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:2.7-enzyme-stub