Английская Википедия:Glycineamide ribonucleotide

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Шаблон:Chembox

Glycineamide ribonucleotide (or GAR) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA.[1][2][3] The vitamins thiamine[4] and cobalamin[5] also contain fragments derived from GAR.[6]

Файл:Phosphoribosylamine.svg
Phosphoribosylamine (PRA)

GAR is the product of the enzyme phosphoribosylamine—glycine ligase acting on phosphoribosylamine (PRA) to combine it with glycine in a process driven by ATP. The reaction, Шаблон:EC number forms an amide bond:[7]

Шаблон:Chem + Шаблон:Chem + ATP → Шаблон:Chem + ADP + Pi

The biosynthesis pathway next adds a formyl group from 10-formyltetrahydrofolate to GAR, catalysed by phosphoribosylglycinamide formyltransferase in reaction Шаблон:EC number and producing formylglycinamide ribotide (FGAR):[7]

GAR + 10-formyltetrahydrofolate → FGAR + tetrahydrofolate

See also

References

Шаблон:Reflist

Шаблон:Nucleotide metabolism intermediates