Английская Википедия:Glycoside hydrolase family 5

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Шаблон:Short description Шаблон:Infobox protein family In molecular biology, glycoside hydrolase family 5 is a family of glycoside hydrolases Шаблон:EC number, which are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]

Glycoside hydrolase family 5 CAZY GH_5 comprises enzymes with several known activities including endoglucanase (Шаблон:EC number); beta-mannanase (Шаблон:EC number); exo-1,3-glucanase (Шаблон:EC number); endo-1,6-glucanase (Шаблон:EC number); xylanase (Шаблон:EC number); endoglycoceramidase (Шаблон:EC number); xanthanase.[8]

The microbial degradation of cellulose and xylans requires several types of enzymes. Fungi and bacteria produces a spectrum of cellulolytic enzymes (cellulases) and xylanases which, on the basis of sequence similarities, can be classified into families. One of these families is known as the cellulase family A[9] or as the glycosyl hydrolases family 5.[10] One of the conserved regions in this family contains a conserved glutamic acid residue which is potentially involved[11] in the catalytic mechanism.

In a recent study using Molecular Dynamics simulations, a considerable correlation between thermal stability and structural rigidity of members of family 5 with solved structures has been proved.[12]

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Шаблон:Sugar hydrolases Шаблон:Enzymes Шаблон:Portal bar