Английская Википедия:Granulovacuolar degeneration

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Granulovacuolar degeneration refers to the occurrence within neurons of abnormal, fluid-filled bubbles (vacuoles) containing a dense proteinaceous granule.[1] Granulovacuoles occur most commonly in pyramidal neurons of the hippocampus. They are present in small numbers in non-demented elderly people, but increase in frequency in Alzheimer's disease and other tauopathies.[2] In Alzheimer's disease, granulovacuoles proliferate stage-wise in different brain areas, and their prevalence is correlated with the degree of tauopathy, Abeta plaque pathology, and cerebral amyloid angiopathy.[2] Immunohistochemical analyses have found that the inner granule includes several proteins, including tubulin[3] tau protein, TDP-43 and others.[2] Although granulovacuoles and their functional significance are still poorly understood, they have been compared to autophagic vacuoles [4]

Файл:GVDs Wiki Final Bar=20um.jpg
Granulovacuolar degeneration (arrow designates one cluster of vacuoles) in the cytoplasm of pyramidal neurons in the hippocampal formation of a person with Alzheimer's disease. Hematoxylin and eosin stain. Scale bar = 20 microns (0.02mm).

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