A cathedral was built here at the end of the 11th century by Humphrey of Hauteville, Count of Apulia and Calabria, and thus lord of the town. This church was destroyed in the years 1447-1456 by a fire followed by an earthquake, after being refurbished in a Renaissance-Romanesque style. Of the original church only a few Byzantine capitals and frescoes remain. The present cathedral was built in the thirty years following, under the supervision of the bishop Matteo d'Aquino.
The main façade has a large rose window. The altarpieces are made from 17th-century intarsia with polychrome marble and mother of pearl. The ceiling has framed canvases. The church has an altarpiece carved in Bitonto stone (1468) by Guido da Guida. There is a San Michele (1538) carved in mazzaro, a local stone, and attributed to Stefano da Putignano. Along the north nave is a Byzantine fresco of the Madonna del Piede. The oak choir-stalls were made in the 15th century and rebuilt by Bishop Antonio Maria Manzolio (1581-1593).
The adjacent sacristy has a ceiling refurbished by bishop Manzolio, and elaborate presses. The bell-tower was built from a Norman watch tower.[2]