Английская Википедия:Grimm's hydride displacement law

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Grimm's Hydride Displacement Law is an early hypothesis, formulated in 1925, to describe bioisosterism, the ability of certain chemical groups to function as or mimic other chemical groups.Шаблон:RefШаблон:Ref

“Atoms anywhere up to four places in the periodic system before an inert gas change their properties by uniting with one to four hydrogen atoms, in such a manner that the resulting combinations behave like pseudoatoms, which are similar to elements in the groups one to four places respectively, to their right.”Шаблон:Ref

According to Grimm, each vertical column (of Table below) would represent a group of isosteres.

Table 1: Grimm's Hydride Displacement Law

C	N	O	F	Ne	Na
	CH	NH	OH	FH	-
		CH2	NH2	OH2	FH2+
			CH3	NH3	OH3+
				CH4	NH4+

References

1. Шаблон:Note Grimm, H. G. Structure and Size of the Non-metallic Hydrides Z. Electrochem. 1925, 31, 474–480.
2. Шаблон:Note Grimm, H. G. On the Systematic Arrangement of Chemical Compounds from the Perspective of Research on Atomic Composition; and on Some Challenges in Experimental Chemistry. Naturwissenschaften 1929, 17, 557–564.
3. Шаблон:Note Patani, G. A.; LaVoie, E. J. Bioisosterism: A Rational Approach in Drug Design. Chem. Rev. 1996, 96, 3147–3176. (Шаблон:Doi Шаблон:PMID)

Шаблон:Medicinal-chem-stub