Английская Википедия:Growth hormone secretagogue
Шаблон:Short description Growth hormone secretagogues or GH secretagogues (GHSs) are a class of drugs which act as secretagogues (i.e., induce the secretion) of growth hormone (GH).[1] They include agonists of the ghrelin/growth hormone secretagogue receptor (GHSR), such as ghrelin (lenomorelin), pralmorelin (GHRP-2), GHRP-6, examorelin (hexarelin), ipamorelin, and ibutamoren (MK-677),[1][2] and agonists of the growth hormone-releasing hormone receptor (GHRHR), such as growth hormone-releasing hormone (GHRH, somatorelin), CJC-1295,[3] sermorelin,[4] and tesamorelin.[5]
Many of them also induce the secretion of insulin-like growth factor 1 (IGF-1),[6] as well as of other hypothalamic-pituitary hormones such as prolactin and cortisol. The main clinical application of these agents is the treatment of growth hormone deficiency.[7] They also see black market use, similarly to anabolic steroids, for bodybuilding purposes.
GHRH receptor agonists
Peptide
- GHRH (Somatocrinin, GRF, GHRF)
- CJC-1295 (DAC:GRF)
- Modified GRF (1-29) (CJC without DAC)
- Dumorelin
- Rismorelin
- Sermorelin (Geref, Gerel; GHRH (1-29))
- Somatorelin
- Tesamorelin (Egrifta)
Ghrelin (GHS) receptor agonists
Peptide
- Ghrelin (Lenomorelin, GHRL)
- GHRP-1
- GHRP-2 (Pralmorelin; GHRP Kaken 100; GHRP-2; KP-102, GPA-748, WAY-GPA-748)
- GHRP-3
- GHRP-4
- GHRP-5
- GHRP-6 (SKF-110679)
- Alexamorelin
- Examorelin (hexarelin; EP-23905, MF-6003)
- Ipamorelin (NNC 26-0161)
- Relamorelin (RM-131, BIM-28131, BIM-28163)
- Tabimorelin (NN-703)
Non-peptide
- Adenosine
- Anamorelin (ONO-7643, RC-1291, ST-1291)
- Capromorelin (CP-424391)
- Ibutamoren (MK-677, MK-0677, L-163191, LUM-201)
- Macimorelin (AEZS-130, JMV 1843)
- SM-130686
Note that while ulimorelin is a ghrelin receptor agonist, it is not a GHS as it is peripherally selective and has little or no effect on GH secretion.[8] Likewise, Adenosine is capable of eliciting hunger response as a ghrelin agonist but has little to no effect on GH secretion.
See also
References
Шаблон:GH/IGF-1 axis signaling modulators
Шаблон:Systemic-hormonal-drug-stub
