Английская Википедия:Guanabenz

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Шаблон:Short description Шаблон:Refimprove Шаблон:Drugbox Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist that is selective to the alpha-2 adrenergic receptor. Guanabenz is used as an antihypertensive drug used in the treatment of high blood pressure (hypertension).[1][2]

The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.[3]

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.

Research

Guanabenz also has some anti-inflammatory properties in different pathological situations, including multiple sclerosis.[4]

Guanabenz was found in one study to exert an inhibitory effect by decreasing the abundance of the enzyme CH25H, a cholesterol hydroxylase linked to antiviral immunity. Therefore, it is suggested that the drug and similar compounds could be used to treat type I interferon-dependent pathologies and that the CH25H enzyme could be a therapeutic target to control these diseases,[5] including amyotrophic lateral sclerosis.

See also

References

Шаблон:Reflist

Шаблон:Antihypertensives and diuretics Шаблон:Adrenergic receptor modulators

Шаблон:Antihypertensive-stub