Английская Википедия:HLA-A24

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Шаблон:Further2 Шаблон:Infobox monoisoform

HLA-A24 (A24) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α24 subset of HLA-A α-chains. For A24, the alpha, "A", chain are encoded by the HLA-A*24 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2402. A24 and A*24 are almost synonymous in meaning. A24 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A23.

A*2402 has one of the highest "A" frequencies identified for a number of peoples, including Papua New Guineans, Indigenous Taiwanese (Eastern Tribals), Yupik and Greenland [Aleuts]. It is common over much of Southeastern Asia. In Eurasia it is least common in Ireland, and A24 is relatively uncommon in Africa except North Africa and Kenya.

Serotype

Шаблон:Serotype

There are over 90 known A*24 alleles, 69 code for different isoforms and 7 are nulls. A*2403 can also be detected as A2403 serotype.

Associated disease

A24 has a secondary risk factor for myasthenia gravis,[2] Buerger's disease.[3] It is also associated with Type 1 Diabetes (T1D)[4][5] and systemic lupus erythematosus (SLE)[6].

Alleles

Шаблон:AlleleFreq

A*2402 is a secondary risk factor,[7] alters type 1 diabetes risk,[8][9] and allele associated with thymoma-induced myasthenia gravis.

Haplotypes

HLA A24-B35 haplotype by Cw frequencies
freq Rank in
ref. Population (%) Pop.
[10] Java (Indonesia) 8.0 1 4
[10] S. Amer. Native 6.3 1 3
[10] N. Amer. Native 5.4 1 5
[10] Mexican 4.7 1
[10] Inuit 4.2 1
[10] Brazilian 3.8 1
[10] Austria 3.5 1
[10] Portuguese 3.1 1 3
[10] Yakut 2.9 1
[10] Mongolian 2.7 1
[10] Timor 2.5 1 5
[10] Bharghavas (India) 2.4 1
[10] Greek 2.3 1
[10] Italian 2.2 1
[10] Mongolian 1.9 1
[10] Vietnamese 1.8 1
[10] Japanese 1.6 2
[10] French 1.2 2
1 Cw4. 2 Cw9.

A24-Cw7-B39
A24-Cw10-B60
A24-Cw10-B61
A24-B48

A24-Cw4-B35

This particular haplotype is common across a fairly wide region, possibly the most widely spread A-Cw-B haplotype in humans. Cw4-B35 has a node within the region once referred to as Thracia/Dacia.

A24-Cw*14-B51

HLA A24-CBL-B51 (CBL=1402) haplotype frequencies
freq
ref. Population (%)
[10] Korean 3.5
[10] Iyers 3.4
[10] Mongolian 2.9
[10] Japanese 2.6
[10] Romanian 2.2
[10] Greek 2.1
[10] Hungarian 2.0
[10] Italian 0.6

Шаблон:Clear left

References

Шаблон:Reflist

Шаблон:HLA-A serotypes