Английская Википедия:HLA-DR14

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Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR14
Haplotypes groups DRA*01:DRB1*1401 DRA*01:DRB1*1402 DRA*01:DRB1*1403 DRA*01:DRB1*1404 ....
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRAШаблон:Dead link
EBI-HLA DRA*0101
Identifiers
beta 1 *1401 to *1408 *1410
Symbol(s) HLA-DRB1Шаблон:Dead link
EBI-HLA DRB1*1401 Шаблон:Webarchive
EBI-HLA DRB1*1402
EBI-HLA DRB1*1403
EBI-HLA DRB1*1404
EBI-HLA DRB1*1405 Шаблон:Webarchive
EBI-HLA DRB1*1406
Shared data
Locus chr.6 6p21.31

HLA-DR14(DR14) is a HLA-DR serotype that recognizes the DRB1*1401 to *1408, *1410 to *1418, and other *14 gene products. DR14 serotype is a split antigen of the older HLA-DR6 serotype group which also contains the similar HLA-DR13 antigens.

Alleles

DR14, DR6 and other serotype recognition of some DRB1*14 alleles[1]
DRB1* DR14 DR6 DR13 Sample
allele % % % size (N)
1401 74 14 3 1942
1402 61 13 9 204
1403 72 12 2 37
1404 79 8 80[2]
1405 86 10 58
1406 37 15 22 117
1407 90 10
1408 25 4

[3]

1410 >75 4

Serotypes are unknown the following alleles: DRB1**1409, *1419 to *1462

Disease associations

DRB1*1402: juvenile rheumatoid arthritis,[4] increased longevity in Okinawans.

Extended linkage

DR*14:DQ5 haplotype: increased risk for non-AChR autoantibodies in myasthenia gravis.[5]

Genetic Linkage

DR14 Haplotypes
DRA DRB1 DRB3
DR14(6)-DR52 *0101 *1401 *0201
*0101 *1402 *0201
*0101 *1403 *0101
DQA1 DQB1 DRB1
DR14-DQ5(5.3, 1) *0104 *0503 *1401
HLA-A HLA-B DRB1
A11-B35-DR14(6) *1101 *3501 *1401
A2-B51(5)-DR14(6) *0201 *5101 *1401

HLA-DR13 is genetically linked to HLA-DR52[6] and HLA-DQ5 (HLA-DQ1) serotypes.

References

Шаблон:Reflist Шаблон:DR serotypes