Английская Википедия:HLA-DR15
Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen | |
major histocompatibility complex, class II, DR15
| |
Haplotypes groups | DRA*01:DRB1*1501 - to - DRA*01:DRB1*1505 DRA*01:DRB1*1507 |
Structure (See HLA-DR) | |
Identifiers | alpha *0101
|
Symbol(s) | HLA-DRAШаблон:Dead link |
EBI-HLA | DRA*0101 |
Identifiers | beta 1 *1501 to *1505 *1507
|
Symbol(s) | HLA-DRB1Шаблон:Dead link |
EBI-HLA | DRB1*1501 |
EBI-HLA | DRB1*1502 |
EBI-HLA | DRB1*1503 |
EBI-HLA | DRB1*1504 |
EBI-HLA | DRB1*1505 |
EBI-HLA | DRB1*1507 |
Shared data | |
Locus | chr.6 6p21.31 |
HLA-DR15 (DR15) is a HLA-DR serotype that recognizes the DRB1*1501 to *1505 and *1507 gene products. DR15 is found at high levels from Ireland to Central Asia. DR15 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR16 antigens.
Serology
DRB1* | DR15 | DR2 | DR16 | Sample |
allele | % | % | % | size (N) |
1501 | 76 | 23 | 6428 | |
1502 | 77 | 16 | 676 | |
1503 | 81 | 13 | 286 | |
1504 | >50 | 1 | ||
1505 | >25 | 2 | ||
1507 | >50 | 1 |
Serotypes are unknown for the following alleles: DRB1*1506, *1508 to *1516, *1518 to *1522. DRB1*1517N is a null.
Alleles
Disease associations
DR15 is positively associated Goodpasture syndrome,[2] early age onset multiple sclerosis,[3] pernicious anaemia,[4] sarcoidosis,[5] hypocretin deficiency associated narcolepsy[6][7] and a predisposition for postmenopausal osteoporosis.[8]
DRB1*1501 is positively associated with Goodpasture syndrome,[9][10] juvenile rheumatoid arthritis,[11] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] systemic lupus erythematosus,[14] cervical cancer (human papillomavirus infection),[15] Sjögren syndrome associated with systemic lupus erythematosus,[16] and intermediate uveitis.[17]
DRB1*1502 is associated with systemic lupus erythematosus,[18] systemic sclerosis (SSc) & anti-topoisomerase antibodies.[19]
DRB1*1503 is associated with Chaga's cardiomyopathy,[20] allergic bronchopulmonary aspergillosis,[12] multiple sclerosis,[13] cervical cancer (human papillomavirus infection).[21]
Extended linkage
DRB1*15:DQA1*0102:DQB1*0602 haplotype us associated with cervical cancer risk in (human papillomavirus infection)[21]
DRB1*1502:DQA1*????:DQB1*0501 haplotype is associated with systemic lupus erythematosus[18]
Genetic Linkage
DR15 Haplotypes
| |||
Serotypes | DRA | DRB1 | DRB5 |
---|---|---|---|
DR15(2)-DR51 | *0101 | *1501 | *0101 |
*0101 | *1502 | *0101 | |
*0101 | *1503 | *0101 | |
*0101 | *1504 | *0101 | |
*0101 | *1505 | *0101 | |
*0101 | *1507 | *0101 | |
DQA1 | DQB1 | DRB1 | |
DR15(2)-DQ6(6.2, 1) | *0102 | *0602 | *1501 |
DR15(2)-DQ6(6.1, 1) | *0103 | *0601 | *1502 |
HLA-A | HLA-B | DRB1 | |
A3-Cw7-B7-DR15(2) | *0301 | *0702 | *1501 |
A1-B51-DR15(2) | *0101 | *5101 | *1502 |
HLA-DR15 is genetically linked to HLA-DR51 and HLA-DQ6 (HLA-DQ1) serotypes.
References
Шаблон:Reflist Шаблон:DR serotypes
- ↑ derived from IMGT/HLA
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ 12,0 12,1 Шаблон:Cite journal
- ↑ 13,0 13,1 Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ 18,0 18,1 Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ 21,0 21,1 Шаблон:Cite journal