Английская Википедия:HLA-DR16

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Шаблон:Cs1 config

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
major histocompatibility complex, class II, DR16
Haplotypes groups DRA*01:DRB1*1601 DRA*01:DRB1*1602
Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRAШаблон:Dead link
EBI-HLA DRA*0101
Identifiers
beta 1 *1601 *1602 *1604
Symbol(s) HLA-DRB1Шаблон:Dead link
EBI-HLA DRB1*1601
EBI-HLA DRB1*1602
EBI-HLA DRB1*1604
Shared data
Locus chr.6 6p21.31

HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.

Alleles

DR16, DR2 and other serotype recognition of some DRB1*16 alleles[1]
DRB1* DR16 DR2 DR15 Sample
allele % % % size (N)
1601 41 29 19 703
1602 47 30 16 239
1604 >50 1

Disease associations

DR16 is associated with Chaga's cardiomyopathy,[2] rheumatic heart disease,[3] coronary artery ectasia,[4] and chronic discoid lupus erythematosus.[5]

DRB1*1601 is associated with tuberculosis risk[6]

DRB1*1602: Juvenile rheumatoid arthritis,[7] rheumatic heart disease,[3] Takayasu arteritis Шаблон:Webarchive,[8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,[9][10] melioidosis (Burkholderia pseudomallei infection)[11]

Extended linkage

DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6]

    • *1602:DQA1*0102:DQB1*0502 haplotype: graves disease,[12][13] cervical cancer (human papilloma virus infection),[14] scleroderma[10]
    • *1602:DQA1*05:DQB1*0301 haplotype: rheumatic heart disease,[3] systemic sclerosis[15]

Genetic Linkage

DR16 Haplotypes
Serotypes DRA DRB1 DRB5
DR16(2)-DR51 *0101 *1601 *0101
*0101 *1602 *0101
*0101 *1604 *0101
DQA1 DQB1 DRB1
DR16(2)-DQ5 (5.2, 1) *0102 *0502 *1601
HLA-A HLA-B DRB1
A2-B51(5)-DR16(2) *0201 *5101 *1601

HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.

References

Шаблон:Reflist Шаблон:DR serotypes