Английская Википедия:HLA-DR16
Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen | |
major histocompatibility complex, class II, DR16
| |
Haplotypes groups | DRA*01:DRB1*1601 DRA*01:DRB1*1602 |
Structure (See HLA-DR) | |
Identifiers | alpha *0101
|
Symbol(s) | HLA-DRAШаблон:Dead link |
EBI-HLA | DRA*0101 |
Identifiers | beta 1 *1601 *1602 *1604
|
Symbol(s) | HLA-DRB1Шаблон:Dead link |
EBI-HLA | DRB1*1601 |
EBI-HLA | DRB1*1602 |
EBI-HLA | DRB1*1604 |
Shared data | |
Locus | chr.6 6p21.31 |
HLA-DR16(DR16) is a HLA-DR serotype that recognizes the DRB1*1601, *1602 and *1604 gene products. DR16 is found in the Mediterranean at modest frequencies. DR16 is part of the older HLA-DR2 serotype group which also contains the similar HLA-DR15 antigens.
Alleles
DRB1* | DR16 | DR2 | DR15 | Sample |
allele | % | % | % | size (N) |
1601 | 41 | 29 | 19 | 703 |
1602 | 47 | 30 | 16 | 239 |
1604 | >50 | 1 |
Disease associations
DR16 is associated with Chaga's cardiomyopathy,[2] rheumatic heart disease,[3] coronary artery ectasia,[4] and chronic discoid lupus erythematosus.[5]
DRB1*1601 is associated with tuberculosis risk[6]
DRB1*1602: Juvenile rheumatoid arthritis,[7] rheumatic heart disease,[3] Takayasu arteritis Шаблон:Webarchive,[8] systemic sclerosis (SSc) & anti-DNA topoisomerase I (anti-topo I) antibody,[9][10] melioidosis (Burkholderia pseudomallei infection)[11]
Extended linkage
DRB1*1601:DQA1*0102:DQB1*0502 haplotype is associated with tubeculousis risk [6]
Genetic Linkage
DR16 Haplotypes
| |||
Serotypes | DRA | DRB1 | DRB5 |
---|---|---|---|
DR16(2)-DR51 | *0101 | *1601 | *0101 |
*0101 | *1602 | *0101 | |
*0101 | *1604 | *0101 | |
DQA1 | DQB1 | DRB1 | |
DR16(2)-DQ5 (5.2, 1) | *0102 | *0502 | *1601 |
HLA-A | HLA-B | DRB1 | |
A2-B51(5)-DR16(2) | *0201 | *5101 | *1601 |
HLA-DR16 is genetically linked to HLA-DR51 and HLA-DQ5 serotypes.
References
Шаблон:Reflist Шаблон:DR serotypes
- ↑ derived from IMGT/HLA
- ↑ Шаблон:Cite journal
- ↑ 3,0 3,1 3,2 Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ 6,0 6,1 Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ 10,0 10,1 Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal