Английская Википедия:HLA-DR5

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Файл:DR Illustration.PNG
Illustration of HLA-DR

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

Serology

DR11, DR5 and DR12 recognition of the gene products of some DRB1*11 and DRB1*12 alleles[1]
DRB1* DR11 DR5 DR12 Sample
allele % % % size (N)
11:01 92 5 3474
11:02 89 3 430
11:03 89 4 397
11:04 87 4 2119
11:05 75 4
11:06 20 73 15
11:07 >50 1
11:08 >50 2
11:09 80 20 5
.
DR12 DR5 DR11 Sample
12:01 83 4 2 893 [2]
12:02 89 162
12:03 >50 3
12:06 >50 2

Except for a few DRB1* alleles, the reactivity of DR5 is relatively poor.

Disease associations

DR5 is associated with persistent generalized lymphadenopathy[3] and Kaposi's sarcoma in AIDS,[4] juvenile rheumatoid arthritis,[5][6] pernicious anemia, Hashimoto's thyroiditis,[7][8] mycosis fungoides,[9] polyglandular deficiency syndrome,[10] systemic sclerosis,[11][12] childhood epilepsy,[13] early-onset alopecia areata,[14] short-ragweed Ra6 allergy,[15] primary antiphospholipid syndrome,[16] and increased longevity in the Dutch.[17]

Genetic linkage

HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

References

Шаблон:Reflist Шаблон:DR serotypes