Английская Википедия:HLA-DR8

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Шаблон:Cs1 config

Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen
human major histocompatibility complex, class II, DR8
Haplotypes groups DQA*01:DRB1*0801 to

DQA*01:DRB1*0806

Structure (See HLA-DR)
Identifiers
alpha *0101
Symbol(s) HLA-DRAШаблон:Dead link
EBI-HLA DRA*0101
Identifiers
beta 1 *0801 to *0806
Symbol(s) HLA-DRB1Шаблон:Dead link
EBI-HLA DRB1*0801
EBI-HLA DRB1*0802
EBI-HLA DRB1*0803
EBI-HLA DRB1*0804
EBI-HLA DRB1*0805
EBI-HLA DRB1*0806
Shared data
Locus chr.6 6p21.31

HLA-DR8 (DR8) is a HLA-DR serotype that recognizes the DRB1*0801 to *0807, and *0810 to *0812 gene products.

Serology

DR8 serological recognition of the gene products of some DRB1*08 alleles[1]
DRB1* DR8 Sample
allele % size (N)
0801 95 1076
0802 96 265
0803 88 230[2]
0804 93 186
0805 >60 5
0806 >75 13

The serological reaction of DR8 is relatively good. The serology of DRB1*0808, *0809 and *0813 to *0832 serotypes is unknown.

Disease associations

DR8 is linked to papillary thyroid carcinomas,[3] early onset pauciarticular juvenile chronic arthritis,[4][5] primary biliary cirrhosis[6]

by allele

HLA-DRB1*0801 is linked to primary biliary cirrhosis[7] In Mexicans DR8 is found more often in type-2 juvenile diabetes.[8]

HLA-DRB1*0803 is also linked to primary biliary cirrhosis[7]

Genetic Linkage

DR8 Haplotypes
DRA DRB1
Haplotypes *0101 *0801 *0101
DQA1 DQB1 DRB1
Haplotypes *0401 *0402 *0801
HLA-A HLA-B DRB1
Haplotypes *0000 *0000 *0801

HLA-DR8 is not genetically linked to HLA-DR51 to DR53, but is linked to DQ4 serotypes.

References

Шаблон:Reflist Шаблон:DR serotypes