Английская Википедия:HMG-box

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Шаблон:Short description Шаблон:Pfam box In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding.[1] The domain is composed of approximately 75 amino acid residues that collectively mediate the DNA-binding of chromatin-associated high-mobility group proteins. HMG-boxes are present in many transcription factors and chromatin-remodeling complexes, where they can mediate non-sequence or sequence-specific DNA binding.[2]

Structure

The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).[3]

Function

HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity.[1] HMG-box domains are found in some high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin.[3] The single and the double box HMG proteins alter DNA architecture by inducing bends upon binding.[4][5]

References

Шаблон:Reflist

External links

Шаблон:Protein-stub